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The development of DFU begins with a mechanical injury or pressure on the foot, often due to neuropathy, which impairs the ability to sense pain and prevent tissue damage
Ann Neurol 70(3):402409 Jang J et al (2016) 25-Hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
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10.3390/nu13051722 151
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