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96 MAO-B inhibition can result in higher levels of neurotransmitters like dopamine, while PDE inhibition can lead to changes in neurotransmitter signal transmission

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These comorbiditiesalso known as non-communicable diseases (NCDs)reduce the quality of life and life span and increase public health costs [3, 5]

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Vohnout, B., de Gaetano, G., Donati, M

In the second case report, the infant showed acute mitochondrial encephalopathy, accompanied by increased level of lactate in the blood and cerebrospinal fluid as well as abnormal levels of -ketoglutarate in the urine