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For skin whitening purposes, Glutathione is administered through intravenous (IV) injections, allowing it to directly enter the bloodstream and inhibit melanin production, the pigment responsible for skin color

In pristane-induced lupus, Lactobacillus strains reduce Th17 frequency by inhibiting IL-1/NLRP3 inflammasome signaling and upregulating TGF-/Smad3 to expand Tregs (120)

3.1.2 Other PEDs This group included other substances prohibited by WADA, such as non-approved substances (BPC-157) from Section S0, other anabolic agents (clenbuterol and SARMs) from Subsection S0, S1.2, peptide hormones and their releasing factors (AOD-9604, hGH 176-191, CJC-1295, ibutamoren, ipamorelin, and growth hormone-releasing peptide) from S2.2, growth factors and growth factor modulators (thymosin-4 and its derivative TB-500) from S2.3, beta-2 agonists (salbutamol and indacaterol) from S3, metabolic modulators (meldonium, GW1516, SR9009, SR9011, and insulins) from Section S4.4, and thyroid hormones

These mediators directly participate in pathogen clearance and activate the expression of pro-inflammatory factors, creating a positive feedback loop with pro-inflammatory cytokines ( IL-15 , IL-10 , TNF- , CASP3 , and CASP9 (Yang et al., 2019)

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