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Description
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The administered doses vary widely, ranging from nanomolar concentrations to milligrams per kilogram, with treatment regimens encompassing both single-dose administrations and prolonged protocols lasting several weeks
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, malondialdehyde, lipid peroxides, 8-isoprostane, and 4-hydroxy-2-nonenal) via OxS-mediated lipid peroxidation, leading to cellular membrane damage[46]
Interestingly, S3I-201 treatment also induced the accumulation of glucagon around the nucleus (Fig
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