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Amylin202306(CagriSema)HbA1C -1.3% 156% IncretinAmylin IncretinAmylin/CagriSemaAmylinCagrilintideIncretinSemaglutide Incretin IncretinGLP-1, GLP-2, GIPGLP-1GIPGLP-1(Glucagon-like peptide-1)IncretinSemaglutideGLP-1 RA GLP-1GLP-1(GLP-1 based analogues)(Heloderma suspectum) exendin-4(Exendin-4 based peptides)/()()/SemaglutideGLP-1 Amylin AmylinIncretinAmylin 100:1 Incretin Amylin 1987 Amylin Amylin SymlinByetta Bydureon SymlinPramlintideAmylinByetta BydureonIncretinAmylinIncretin2002Amylin3.25GLP-1Exendin-4 base peptideByettaByettaBydureonAmylinSymlinPramlintideinsulin Amylin20127BMS53AmylinAZ 34 Amylin BMS/AZ201312AZBMSAmylinAmylinAmylin (Novo Nordisk) CagrilintideAmylin SemaglutideCagriSema 2023ADA2023GLP-1 RA(Ozempic, Wegovy, Semaglutide)GLP-1 RA(Rybelsus, Semaglutide)(Tirzepatide, dual GIP/GLP-1 receptor agonist)Amylin+GLP-1 RACagriSema 32 2 17 2 BMI 27 kg/m 2 Metformin SGLT2 (1:1:1) CagriSema Semaglutide Cagrilintide 2 .4 HbA1CCagrilintide-0.9%Semaglutide-1.8%-0.5%CagriSema-2.2%CagriSema Cagrilintide-8.1%Semaglutide-5.1%CagriSema-15.6%-5%CagriSema-15.6% (Time in Range, 70-180mg/dL)CagriSema88.9%70-180mg/dLTIR70%HbA1C7%TIR 2 3 32 CagriSema 21 68% Semglutide 22 71% Cagrilintide 24 80% Amylin

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