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Based on structural and functional similarities, the superfamily is divided into 5 main subfamilies: Ras, Ran, Rho, Arf and Rab family

10.1080/10408398.2019.1653260 30 GadadB

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Both, the chaperone sortilin and the exoproteolytic enzyme carboxypeptidase E, bind to the BDNF pro-domain and play an important role in sorting of BDNF to vesicles of the regulated pathway of secretion (Chen et al