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Kassab AE, Gedawy EM

Cases of severe hepatic adverse drug reactions including hepatitis, cholestasis or hepatic failure including death have been reported in patients with serious underlying medical conditions (e.g., hematologic malignancy) during treatment with azole antifungal agents, including CRESEMBA

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Without a doubt, the most critical contraindication is any known copper metabolism disorder, such as Wilsons disease

S., Kawathe, P
