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While there is a chain of positive signals from Met activation to Akt and ERK phosphorylation, numerous feedback loops and crosstalk between the Akt and ERK arms of the pathway have caused drug development against these targets to be particularly challenging

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It has shown behavioral efficacy at three different doses in a mouse model of depression (novelty suppressed feeding) after daily oral administration for 28 days (Data on file, Neuralstem, non-peer-reviewed)