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doi: 10.1016/j.jchromb.2006.11.033

The Mechanism of Action of Biguanides: New Answers to a Complex Question
Through SASP, senescent cells may permanently confer a state of stemness in neighboring cells and thereby impair tissue function and renewal, an effect which we recently described in the senescence-stem lock model for aging (de Keizer, 2017)

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that's the problem, and it should be shut down)," he said, expressing concern about non-medical personnel administering such procedures

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