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In addition to this, there are some medical conditions like pernicious anemia or gastrointestinal disorders, where malabsorption is the main problem

The term allergy was first coined in the early 1900s by Clemens von Pirquet (18741929), who was the first to recognize that antibodies not only mediate protective immune responses but can also be the cause of hypersensitivity reactions [9]

Furthermore, studies have reported an aberrant activation of NRF2, a key antioxidant transcription factor involved in the regulation of critical antioxidants including glutathione, SOD, and CAT, leading to reduced antioxidant capacity (Davinelli et al., 2025) In ASD children, the oxidative stress is not only higher, but it manifests in a complicated new pattern concerning different types of ROS and antioxidants (Hirayama et al., 2020)

Internal changes during this phase include upregulation of collagen genes, increased growth factor production, and early accumulation of new extracellular matrix components

10.1089/ars.2007.1663 Antioxid Redox Signal

27 Point mutations in the DNA gyrase or topoisomerase IV genes confer fluoroquinolone resistance