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Methods Plasma levels of PGA, kynurenine, and tryptophan were quantified by liquid chromatography-mass spectrometry in cohorts comprising healthy TTR wild-type controls, asymptomatic carriers of the TTR-V30M mutation, and symptomatic patients with TTR-V30M amyloidosis

Tear fluid was collected from 60 participants, cognitively normal (CN) individuals (n=32), patients with mild cognitive impairment (n=14), and dementia (n=14)