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Spatial omics now allow us to pinpoint the location of GPX4 cells, identify glycolytic versus OXPHOS niches, and visualize how these regions spatially align with, and suppress, infiltrating T cells

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Clinicians use certain staging systems for OSF clinical diagnosis and treatment (Passi et al., 2017)

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10.1016/j.fct.2020.111823 135 WangK.MengX.GuoZ

Epigenetic and MicroRNA Regulation In addition to genetic susceptibility, epigenetic modifications, such as DNA methylation, histone acetylation, and microRNA (miRNA) regulation, play critical roles in the pathogenesis of hypertension-induced kidney injury