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Dichloroacetate potentiates tamoxifen-induced cell death in breast cancer cells via downregulation of the epidermal growth factor receptor

Cordova D et al

Increases in cGMP result in the inhibition of plasma membrane localized L-type Ca 2+ channels resulting in decreasing overall intracellular Ca 2+ which normally serves to activate myosin light chain kinase leading to vasoconstriction

Causes include untreated diabetes, the loss of bicarbonate in your body and kidney conditions

10.1038/nrn2573 [DOI] [PubMed] [Google Scholar] Sauer SW, Merle U, Opp S, Haas D, Hoffmann GF, Stremmel W, & Okun JG (2011)
