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Therefore, the consistent beneficial effects of BPC 157 therapy exclude poorly controlled NO increase (and therefore the consequent chain of negative events) (see below, Section 3.2) and poorly controlled effects on the increase of NOS gene expression (NOS-1, NOS-2, and NOS-3 gene expression)

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Despite advances in surgical and pharmacological interventions, the persistence of such symptoms diminishes quality of life and daily functioning of patients ( A key pathological mechanism implicated in SCI and DCM is neuroinflammation driven by prolonged activation of microglia and macrophages (M/M) in the central nervous system ( Knowledge of the distribution of M/M in brain-spinal cord lesions in the chronic phase, including differences between those in SCI and DCM, is crucial for comprehending the underlying mechanisms and developing new treatment approaches for NeP in patients with SCI and DCM

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They modulate the stress response and may alleviate insomnia related to anxiety or depression