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Science 334 , 678683 (2011)
Goulas, A., Betzel, R
M., Mahadik S
The ATM specific kinase inhibitor KU60019 (Tocris, UK) was dissolved in DMSO to 100 mM then diluted to 5 M directly into media
It is engineered to have a higher biological potency than native IGF-I or IGF-II and has several advantages over recombinant insulin
Notably, 50% of patients develop cholestasis following a liver transplant, and 12% of cholestatic patients experience cyclosporine toxicity (Pecorella et al., 1990)
