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however, dopamine agonists or levodopa are used if response is suboptimal (Connolly & Lang, 2014) patients taking MAO-B inhibitors are more likely to require additional supplemental drug therapy within 2-3 years compared to patients taking levodopa (Pringsheim T et al, 2021) MAO-B inhibitors used to treat PD: Selegiline (most commonly used) Safinamide (newest) COMT inhibitors ineffective when given alone, but may prolong & potentiate the effect of levodopa (Spindler 2024) COMT inhibitor used in PD: Amantadine amantadine has weak anti-PD effects with low toxicity, and seems to be most useful in young patients with mild PD

Blue or green skin discoloration Perhaps the most alarming, though least harmful, side effect is temporary skin discoloration

Concentrations of BHB ranging from 0.5 to 3 mmol/L may confer beneficial effects on tissue metabolism, a state commonly referred to as nutritional ketosis

Cooper AJL, Tate SS

However, always consult with a healthcare provider if you have underlying health conditions or take prescription medications