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At the same time, ellagic acid also prevented the decrease of the mitochondrial membrane potential ( Yet another phenolic acid, rosmarinic acid, has been found to reduce the amount of reactive oxygen species and malondialdehyde, which in turn attenuates cellular oxidative stress and protects hydrogen peroxide-treated glial cells (Lee et al., 2008) on SH-SY5Y (human dopaminergic neuron cells) by controlling the upregulation of Bax and the downregulation of Bcl-2, and reduce mitochondrial membrane potential by reducing reactive oxygen species

Ham JR, Lee HI, Choi RY, Sim MO, Seo KI, Lee MK

The mechanisms of action may be mediated through the reduction of the production of NO, free radicals and pro-inflammatory cytokines

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