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The study concluded that this course of capsaicin treatment was well-tolerated, had no negative functional or neurological effects, and did not decrease safety compared with standard of care alone

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Given the prevalence of anxiety and depression in these patients, which ranges from 13 to 80% [118], antidepressants and antiepileptic drugs, which have been shown to be effective in the majority of patients, could also have a positive effect on pain symptoms and could be an indication for pharmacological treatment at the first approach

Less consistent evidence across analyses were found for an association between higher C3 levels and an anhedonic symptom profile previously linked with inflammation and neurobiological reward processes

A three-dimensional model of neural activity and phenomenal-behavioral patterns
