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Further to safety and immunogenicity, production, transport and storage considerations will also have to be taken into account for successful implementation of vaccines in range countries

Published rodent serum half-life estimates cluster in the range of minutes to a few hours short, by the standards of therapeutic peptides

In orthotopic and postsurgical TNBC mouse models, MND-ART-GEL significantly inhibited tumor growth and recurrence, remodeled the immunosuppressive tumor microenvironment, enhanced CD8 + T-cell infiltration, dendritic cell maturation, and M1 macrophage polarization, reduced PD-1/PD-L1 expression on CD8 + T cells, and promoted the secretion of immune-related cytokines

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Further randomized and well-controlled studies are needed to confirm these preliminary findings

Depending on the desired concentration, reconstituting 5mg peptide with 2-3mL of bacteriostatic water or preferred solvent is a good rule of thumb
