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Only a limited number of patients who were allergic to allopurinol have been studied to date, but the drug was tolerated in those patients

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Prior proteomics studies also showed a decrease in proteins uromodulin (UROM), kininogen-1 (KNG1), basement membrane-specific heparan sulfate proteoglycan core protein (PGBM), and nidogen-1 (NID1) in the urine of IC/BPS patients relative to controls 21,22

Drug Interactions: Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays

The corresponding movie is shown in Supplementary Video 4
