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Thinking regenerative medicine is only for the elite athletes or the rich and famous

Tipe2 gene transfer ameliorates aging-associated osteoarthritis in a progeria mouse model by reducing inflammation and cellular senescence

The National Academy of Medicine set no upper tolerable limit

They already have minimal b12 intake

As shown in Section Riboflavin Ameliorates Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation, riboflavin has antioxidant properties and upregulates antioxidant enzymes especially SOD, also, supplementation with riboflavin will elevate the intra-mitochondrial FAD levels compensating for the decline in the capacity to assemble of dysfunctional mitochondrial complexes

[sciencedaily.com May 8, 2019] "For people predisposed to heart disease, we know that changes in diet and exercise can help stave off the disease, but there is nothing like that for severe mental disorders yet," adds author Sedlak