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Brown, J., Crawford, T

When the dose exceeds 10 Gy, severe damage to intestinal epithelial cells occurs, primarily manifesting as gastrointestinal symptoms such as abdominal pain, vomiting, and bloody stools [123]

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations AA, Artocarpus Altilis

Chronic ethanol intake also suppresses the activity of peroxisome proliferator-activated receptor-alpha (PPAR), which is a nuclear hormone receptor that upregulates the expression of many genes involved in the transport and beta-oxidation of free fatty acids (FFAs), including the gene encoding carnitine palmitoyltransferase 1 (CPT1) in mitochondria (Zhang et al., 2018a)