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doi: 10.1177/1933719116667226 [DOI] [PubMed] [Google Scholar] 29

LINK Tubbs RS, Loukas M, Shoja MM, Cohen-Gadol AA: John Murray Carnochan (1817-1887): the first description of successful surgery for trigeminal neuralgia

Although neurons activate compensatory NAD + salvage through nicotinamide phosphoribosyltransferase (NAMPT) [108], this pathway fails to offset PARP-1-driven NAD + catabolism during stroke [106], resulting in sustained sirtuin suppression and disrupted mitochondrial dynamics

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Subsequently, the increased histone lactylation facilitates the transcriptional activation of HIF-1 targets such as Bmp5, Trpc5, and Kit, thereby promoting PASMC proliferation and vascular remodeling