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The increased activity can be attributed to improved binding affinity to pituitary receptors, enhanced resistance to inactivation, and a conformational change induced by type II bending

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Elsevier, Amsterdam, pp 326362 Maselli J, Hales BF, Chan P, Robaire B (2012) Exposure to bleomycin, etoposide, and cis-platinum alters rat sperm chromatin integrity and sperm head protein profile1