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Further work suggests that TB-500 may activate two cell-signaling pathways

Oxidative stress and mitochondrial dysfunction are considered central features of neurodegenerative diseases [26], and the long-term use of KD may positively affect mitochondrial function through several mechanisms

Extended data Extended Data Fig

Tomato ABSCISIC ACID STRESS RIPENING1 (ASR1) protects yeast from osmotic stress by inducing downstream components of the high-osmolarity glycerol pathway (Moretti et al., 2006)

SLC25A43 KO in HER2-positive breast cancer cells (BT-474) increases proliferation and cell cycle progression via enhanced G1-to-S transition, suggesting a role for SLC25A43 as a regulator of the cell cycle through a putative mitochondrial checkpoint [232]