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After initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)

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Zinc Demand During Illness and Stress Zinc requirements may increase during: Acute or recurrent illness Chronic stress or poor sleep Increased inflammatory burden Periods of high physical or cognitive demand During illness, zinc is rapidly utilized by immune cells

The Adult and Adolescent ARV Guidelines denote this category as Other Initial Antiretroviral Regimens for Certain Clinical Scenarios (Table 3).[69] Special Considerations for Women of Childbearing Potential The Adult and Adolescent ARV Guidelines have specific recommendations for women trying to conceive or who are sexually active and not using effective contraception, and may become pregnant.[70,71] Based on updated data, preferred options when there is a potential for pregnancy include bictegravir-tenofovir alafenamide-emtricitabine or dolutegravir plus preferred NRTI backbone (tenofovir alafenamide or tenofovir DF, with either emtricitabine or lamivudine).[70,71] The Perinatal HIV Clinical Guidelines recommend the same preferred options during pregnancy.[70,71,72] Thus, if a woman is taking one of these preferred antiretroviral regimens and becomes pregnant, she can continue on the same regimen.[72] Ritonavir-boosted darunavir (in combination with a preferred NRTI backbone) is also a preferred option for use during pregnancy, though it may have more side effects and drug interactions