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328 ADI-PEG-20, in combination with pemetrexed and cisplatin (ADIPEMCIS), was well tolerated in another phase I study of recurrent high-grade glioma (HGG) (NCT02029690)

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It is essential to know the corresponding efflux transporters for drugs and possess appropriate inhibitors, and typically more than one efflux system is involved in the drug efflux process ( 2.2 Drug modification Another way to enhance brain delivery of drugs may alter the physicochemical properties of a drug by modifying it, which in turn improves the transmembrane transport of the drug