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Numerous anti-cancer studies have proposed targeting iron with chelators to decrease the labile iron pool (LIP), however, the non-specificity of this strategy results in serious side effects [15]

15 HeirmanI.GinnebergeD.Brigelius-FlohR.HendrickxN.AgostinisP.BrouckaertP.et al (2006)

Middelkamp-Hup MA, Bos JD, Rius-diaz F, Gonzalez S, Westerhof W

Induction of p53 transcription and apoptosis by XPO1 inhibition in mantle cell lymphoma

Newell, J