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Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events

351 Genetic inhibition of PPARG significantly restores the impaired anti-tumor activities of ferroptotic DCs in vivo

and 4) SEV (endpoint B) vs

Accumulation of organic and inorganic peroxides in the blood of those patients plays a pivotal role in the depletion of erythrocyte GPx activity [78], which is further aggravated by deficiency of micronutrient antioxidants in the blood of those patients [56,57]

ROS-induced damage can be prevented by CoQ10 in the neuronal cells and astrocytes

doi: 10.1016/S0378-1119(98)00485-5