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Studies in adipocyte cell culture and in rodent metabolic models have used LR3 to characterize these effects

in a hospital audit of injection practice, vials whose rubber diaphragm was never disinfected before withdrawal were part of why contamination rates ran high

Goerner A, Reichstein M, Tomelleri E, Hanan N, Rambal S, Papale D, Dragoni D, Schmullius C

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At standard doses of 1 mg or less daily, side effect rates were similar to placebo

However, very high doses taken over long periods can potentially cause nerve issues or mask other nutrient deficiencies