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While B12 deficiency can affect anyone, certain groups are at a higher risk

Instead, humans are dependent solely on dietary sources of vitamin B12 from: (a) methyl- and 5'deoxyadenosyl forms of vitamin B12 present in animal-source foods, which reach the small intestine (Sobczynska-Malefora & Smith, 2022) or (b) crystalline B12 in fortified foods or dietary supplements

doi: 10.1016/S0024-3205(97)00744-3

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One key study has demonstrated that MET/HGF signalling is involved in mediating the recruitment of neutrophils into the TME, and as such is thought to play a role in regulating tumour immunity to some therapies [93]

This would suggest that 3D cultures may be used to study MB behavior and drug sensitivity, mimicking better the in vivo physical conditions (113)