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Nicotine acetylcholine receptors (nACHRs) (Ni et al., 2013) and using an antagonist of 7nAChR can actually inhibit the proliferation of microglia and reduce the expression of inflammatory factors IL-1 and TNF- (Poorthuis et al., 2009), improves neuronal plasticity in the hippocampus (Motaghinejad et al., 2016), and can treat excitotoxicity at low concentrations (Sieber, 2012)
Trendiness aside, does bone broth deserve all the hype

Tang Z, You X, Xiao Y, Chen W, Li Y, Huang X, et al

Cell Stem Cell 8, 468475

Platforms like RosettaVS have been developed to predict docking poses and binding affinities by using enhanced force fields and flexible receptor models to improve prediction accuracy
