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After transportation to the peripheral blood, hephaestin converts Fe2+ to Fe3+

In: Proceedings of the Royal Irish Academy Section B: Biological, Geological, and Chemical Science

Phosphorylated JNK travels into the mitochondria to further phosphorylate many mitochondrial proteins, including the mitochondrial ETC, causing even more ROS leakage and oxidative stress by binding to SH3 homology associated BTK binding protein (Sab) [110, 275]

We detected the effects of GSTM2 on the expression of these two genes

Conversely, ACSL4 expression, along with levels of ROS, MDA, 4-HNE, Fe 2+ , and -synuclein, were markedly elevated, thereby exacerbating ferroptosis and lipid peroxidation in the brain

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