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doi:10.1016/j.ccc.2005.06.002

Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

It is worth mentioning, that also undifferentiated HT-22 cells respond to glutamate-induced cytotoxicity, but only at concentrations of 2.5 mM (He et al., 2003), in differentiated mouse hippocampal HT-22 neurons viability was reduced with 0.1 mM glutamate, additionally indicating that we used differentiated mouse hippocampal HT-22 neurons

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Early exploratory studies have looked at the fragment for cartilage and joint tissue, examining whether its signaling could support the repair of connective tissue under stress