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In the near future, sensitive and specific biomarkers for ROS-induced oxidative stress may offer new opportunities for early diagnosis and staging of MASLD

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Hence, while the BOLD-fMRS estimates obtained in this way remain useful in certain scenarios (especially where a robust BOLD response is to be expected) and offer the great advantage of temporal concurrency with the MRS acquisition, we would caution against relying solely upon this technique in scenarios where the BOLD response may be more subtle or more variable, or where subject conformance may be limited

Mol Cell Endocrinol (2020) 518:111006

Insulin enhances the activity of URAT1