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16 , e1008559 (2020)

Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)

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Altogether hydrogen rich mediums seem to improve the damaging or even reverse in some instances the damaging effects stemming from renal dysfunction and nephrotoxicity