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The congestion is not severe, no fatty degeneration is identified, and only a few degenerated hepatocytes are found
To provide additional support for the notion that PDI plays a crucial role in mediating BSO-induced cell death in HT22 cells, we tested the protective effects of a few known PDI inhibitors, including cystamine, 4-hydroxyestrone (4-OH-E 1 ), bazedoxifene (BAZ) and others
Nutrient-dependent regulation of -cell proinsulin content
Zhou X, Yeasmin Khusbu F, Xie Y, et al
In many cell types, pyruvate carboxylation to oxaloacetate is suppressed, thereby rendering them reliant on glutamine catabolism to replenish the oxaloacetate that can condense with acetylCoA to produce citrate and drive the TCA cycle (DeBerardinis et al , 2007)
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
