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A previous study demonstrated that HFD-fed, STZ-induced, insulin-resistant diabetic mice are good models for patients with T2DM that have risk factors for obesity and distinct metabolic characteristics (35)

doi: 10.1038/s41380-019-0609-8, [DOI] [PMC free article] [PubMed] [Google Scholar] Tang B

Increased intracellular ROS oxidize cysteine residues on KEAP1, leading to NRF2 release and nuclear translocation [130]

Pantethine inhibited the expression of TMPRSS2, the primary host enzyme that SARS-CoV-2 uses to gain entry into cells

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The insulin-like growth factors IGF-1 and IGF-2 play central roles in regulating post-embryonic growth, development, and protein synthesis in poultry through their interaction with growth hormone 60