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Indicatively, the ratio of the minor axis to the major axis of the LV in the end-systolic phase in pulmonary arterial hypertension in control rats was downhill from day 7 on, and severely deteriorated at the latter periods, i.e., at days 14, 21, and 30 (Figure 1 and Figure 2)

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Feb 15 2008;32(2):568-75

PARP1- and CTCF-mediated interactions between active and repressed chromatin at the lamina promote oscillating transcription

A gene modulator is a molecule that can interact with this system to restore a more favorable pattern of expression