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The hypoxia alleviation via O2 production, the redox balance disruption via glutathione consumption and the reactive oxygen species generation, together would down-regulate the expression of O6-methylguanine-DNA methyltransferase under TMZ medication, which is considered as the key to drug resistance

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The morphology of the synthesised materials was confirmed and an electrode was prepared to perform a cyclic voltammetry (CV) in phosphate buffer saline (PBS - pH 7) medium to examine the redox behaviour SMX

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