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75,76 In another randomized controlled trial that included 180 women with PCOS and 150 without, all of whom had serum 25-OH vitamin D levels below 30 ng/mL, those with PCOS who received 20,000 IU (500 mcg) vitamin D per week experienced an improved LH:FSH 77 ratio versus placebo

Recent scientific breakthroughs point to a shared underlying mechanism: profound, systemic oxidative stress and the dysregulation of the body's most critical defense molecule

doi: 10.1016/j.gendis.2018.05.001 2 WangD-YJiangZBen-DavidYWoodgettJRZacksenhausE

Matsuda Y, Maeda Y, Ito M, et al

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J Physiol 594:53295342