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An increasing amount of evidence much of it clinical suggests that migraine is a response to cerebral energy deficiency or oxidative stress levels that exceed antioxidant capacity and that the attack itself helps to restore brain energy homeostasis and reduces harmful oxidative stress levels

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Demographic characteristics and clinical severity assessed using the Childhood Autism Rating Scale (CARS) were not re-analyzed in the current study and are referenced solely for cohort description and verification, in line with transparent reporting practices