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The epithelial tight junction proteins, the most apical component of epithelial intracellular junctions, equip IECs with this function, which seals the paracellular space between the cells and tightly restricts the transport of hydrophilic molecules 22,23,24

DISCUSSION BPC 157 was suggested to be a link between inflammatory bowel disease and multiple sclerosis, that could be also used in practice per-orally (as an anti-ulcer peptide, stable in human gastric juice) (5-7, 9), and thereby, being equally effective against the models of both of those diseases

Micro-channels begin closing within 10 to 15 minutes

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Histology and biochemistry assessment was carried out immediately after sacrifice after paracetamol challenge at 25 min (general seizure initiation), 3 h (at the time of maximal convulsion, used as the point of therapeutic application of BPC 157 regimens) and at 24 h post-paracetamol