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It is the principal upstream regulator of GnRH secretion, integrating sex hormone feedback to determine when and how frequently GnRH and downstream LH is released

18 , e3000780 (2020)

On the other hand, autophagy also generates ROS, which may induce oxidative stress

Acknowledgements This work was supported by grants from the National Basic Research Plan of China (2018YFA0208900), National Natural Science Foundation of China (31571021, 91543127, 31730032 and 31661130152), Innovation Group of the National Natural Science Foundation of China (11621505), Frontier Research Programme of the Chinese Academy of Sciences (QYZDJ-SSW-SLH022), Beijing Municipal Science and Technology Commission (Z161100000116035), National Distinguished Young Scientist Programme (31325010) and the Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS

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