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The antioxidant properties of lipoic acid come from its ability to directly scavenge ROS, its metal-chelating activity, and its potential to react with and promote regeneration of other antioxidants such as glutathione and vitamins E and C
As the principal bioactive constituent of turmeric, curcumin has been extensively investigated for its capacity to modulate multiple signaling pathways, including NF-B, mitogen-activated protein kinase, and phosphatidylinositol 3-kinase/Akt (PI3K/Akt) cascades, which play pivotal roles in regulating inflammatory responses, cellular proliferation, and apoptotic processes (Qiu et al., 2020
For instance, nanoparticles can be engineered to deliver antifibrotic drugs directly to activated HSCs, thereby reducing ECM production and fibrosis progression [15]
Chapter 27 - Failed Cartilage Repair
