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114 In the context of ALS, the interaction of CCS with mutant SOD1 is faulty, resulting in decreased delivery of Cu to the mitochondria and the accumulation of the less-stabilized SOD1, which is prone to acquire pro-oxidants, consequently causing a toxic gain-of-function effect in motor neurons

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Vitamin Cs Role : Although not a substitute for sunscreen, Vitamin C provides an additional layer of defense by neutralizing free radicals generated by UV radiation, thus reducing inflammation and decreasing the risk of sunspot formation

doi: 10.1016/j.crmicr.2024.100245 108 ElFekyD

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Its safety is supported by its natural presence in the body and homeostatic regulation, which prevents copper toxicity (Pickart, 2010)