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Although all of the available studies have methodological limitations, the weight of the evidence supports the conclusion that valproate exposure in utero can cause decreased IQ in children

TPN (especially if it only contains essential amino acids, but not ornithine)

Vitamin B 12 deficiency that results from pernicious anemia can easily be corrected with high-dose daily supplementation or with monthly intramuscular injections of the vitamin (see the article on Vitamin B 12 )

doi: 10.1074/jbc.M114.595363 52 WaltA.KahnM

MECHANISM OF LOCAL ANESTHETIC TOXICITY Local anesthetics are generally safe and effective when limited to the site of therapy, such as tissue infiltration, near a nerve or a plexus of nerves

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