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The conclusion was that alisporivir at a dose of 1200 mg twice daily for 15 days had a significant viral inhibitory effect against HCV-1, HCV-3 and HCV-4.[91] In another study in treatment-nave patients, alisporivir had potent activity against the four most prevalent genotypes of HCV (HCV-1: -4.61 1.88

Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease

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When lysine is the substrate instead of glycine, the enzyme does not catalyze the synthesis of guanidinoacetate (Arg + Gly Orn + guanidinoacetate), the precursor of creatine, but the synthesis of homoarginine (Arg + Lys Orn + homoarginine)

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