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The study from SLE patients showed an increase expression of Fas/Fas ligand and caspase-3 activity in T cells with a consequent increase in T lymphocyte apoptosis [50,108]

The rate-limiting toxicities are neutropenia, thrombocytopenia and anemia

Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17/Treg imbalance

Hepatology Research, 13 (1), 1019

US Federal Register

Tabernero J, Grothey A, Cutsem E, Yaeger R, Wasan H, Yoshino T, Desai J, Ciardiello F, Loupakis F, Hong Y, Steeghs N, Guren T, Arkenau H, Garca-Alfonso P, Gollerkeri A, Pickard M, Maharry K, Christy-Bittel J, Anderson L, Kopetz S