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Whereas the sugar thiolate groups were substituted by the histone ligand through the histidine delta nitrogen side chains, the triethyl phosphine groups make hydrophobic interactions with surrounding H3 residues

13,14 Interestingly, stromal cell expression of GS may also be important for cancer growth, suggesting that targeting this mechanism may indirectly reduce tumour cell proliferation

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Tissue that was clearly damaged may demonstrate functional recovery

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